Royal Air Force Typhoon FGR4s have operated alongside France's air force in a coordinated attack targeting an hidden munitions depot in Syrian territory employed by the IS group, as stated by the UK's MoD.
The location, pinpointed through reconnaissance, was assessed as housing weapons and explosive materials, the release indicated, and was located in hills just north of the historic site of Palmyra in Syria's central region.
"Our aircraft utilized Paveway IV guided bombs to target a series of access tunnels down to the site... early reports suggest the strike was effective," the MoD said.
There was no indication of any harm to civilians in the strike conducted Saturday night and each participating jet made a safe return, the defence officials confirmed.
The Typhoon FGR4s were assisted by a Voyager refuelling tanker.
The Islamic State group - also known as the so-called Islamic State - established jihadist rule over parts of Syria and Iraq before its territorial defeat in 2019.
"This action shows our UK leadership, and determination to stand shoulder to shoulder with our allies, to eradicate any re-emergence of the terrorist group and their violent and radical beliefs in the Middle East," the British Defence Secretary the Defence Secretary stated.
UK warplanes have conducted patrols over Syria to "deter any efforts to regroup" of Islamic State after its military defeat at the Baghuz confrontation in the year 2019, the MoD reported.
"I must thank the personnel of British forces involved in this strike for their professionalism and their courage," he said. "Including them were numerous British personnel deployed over Christmas and New Year. This operation, to remove terrorist threats who pose a risk to our way of life, shows how UK forces are ready to step up, continuously, ensuring Britain's security at home and influential overseas."
In December, the American forces executed what it described as a "large-scale strike" targeting IS targets in the country, after an assault resulted in the deaths of two US troops and a civilian interpreter in Palmyra.
The UN reports Daesh still boasts roughly 5-7 thousand militants in Iraq and Syria.